Inhibition of Intrinsic Thrombin Generation
نویسندگان
چکیده
منابع مشابه
Inhibition of Intrinsic Thrombin Generation
BACKGROUND The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood. There are several clinically used inhibitors of intrinsic thrombin generation. Here the inhibitory concentrations 50% (IC50) of these anticoagulants are measured by the highly specific thrombi...
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This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin. Studies have demonstrated that on activation, the amount of one specific lipid, phos...
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ژورنال
عنوان ژورنال: Drug Target Insights
سال: 2006
ISSN: 1177-3928,1177-3928
DOI: 10.1177/117739280600100003